Catecholamines up integrates dopamine synthesis and synaptic trafficking
نویسندگان
چکیده
منابع مشابه
The neuronal trafficking of the neurotransmitter dopamine and its regulation by the membrane protein Catecholamines up in Drosophila melanogaster
The neurotransmitter dopamine and its role in neurological diseases The biogenic catecholamine dopamine (DA) functions mainly as a neurohormone and neurotransmitter. It also functions as an intermediary step in the biosynthesis of norepinephrine and epinephrine, structurally similar catecholamines that serve as cell regulators and neurotransmitters in mammals. The neurotransmitter function of D...
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The regulation of dopamine and serotonin synthesis in rat brain striatal synaptosomes has been studied using HPLC methods. Noradrenaline was shown to markedly inhibit both the synthesis of dopamine and serotonin. The response of the synaptosomes to the concentrations of noradrenaline appeared to be biphasic, a very effective inhibition occurring at low concentrations (1-5 µm) and a relativ...
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Activity-dependent changes in synaptic function are believed to underlie the formation of memories. Two prominent examples are long-term potentiation (LTP) and long-term depression (LTD), whose mechanisms have been the subject of considerable scrutiny over the past few decades. Here we review the growing literature that supports a critical role for AMPA receptor trafficking in LTP and LTD, focu...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2011
ISSN: 0022-3042
DOI: 10.1111/j.1471-4159.2011.07517.x